03/21/2025

The Many, Many Ways Tuberculosis Shaped Human Life

A painting of a man visiting a sick man in bed.
A scene when a character is sick with tuberculosis from the book “Anna Karenina” by Leo Tolstoy. Credit: Shutterstock

Tuberculosis (TB) has had an incredibly large impact on human history. One staggering statistic? It’s been estimated that by the start of the 1800s, the disease had killed one in seven people who had ever lived. Because of this, tuberculosis affected human culture, geography, and fashion—and even killed off some of literature and media’s most famous heroines.

While TB incidence has gone down tremendously in the United States, it remains a massive issue in low-resource nations. About 1.25 million people die of TB each year, making it still the deadliest infectious disease in the world.

Author John Green explores humankind’s relationship with TB in the new book Everything is Tuberculosis: The History and Persistence of Our Deadliest Infection. Green speaks with Host Flora Lichtman about how TB’s path reflects our society and culture. He joins us from Indianapolis, Indiana.

Read an excerpt of Everything is Tuberculosis.


lightbulb The SciFri Book Club is reading Everything Is Tuberculosis together this May! Make sure to enter our giveaway to win a free book, and join our online community space to discuss this read with Book Club members.

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Segment Guests

John Green

John Green is the author of Everything is Tuberculosis. He’s based in Indianapolis, Indiana.

Segment Transcript

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Meet the Producers and Host

About Rasha Aridi

Rasha Aridi is a producer for Science Friday and the inaugural Outrider/Burroughs Wellcome Fund Fellow. She loves stories about weird critters, science adventures, and the intersection of science and history.

About Kathleen Davis

Kathleen Davis is a producer and fill-in host at Science Friday, which means she spends her weeks researching, writing, editing, and sometimes talking into a microphone. She’s always eager to talk about freshwater lakes and Coney Island diners.

About Flora Lichtman

Flora Lichtman is a host of Science Friday. In a previous life, she lived on a research ship where apertivi were served on the top deck, hoisted there via pulley by the ship’s chef.

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