01/31/2025

Scientists Create Glowing ‘RNA Lanterns’ With Bioluminescence

Three blobs of colors, on the left, two green blobs. in the center, two pink blobs. On the right, two green and pink blobs.
Two human cells making RNA made visible by the bioluminescent lantern in pink (middle image). On the left, the same cells making a fluorescent protein that’s distributed evenly throughout the two cells. The right image is an overlay of the two, emphasizing that the RNA is distributed unevenly and is concentrated at specific locations. Credit: UC Irvine

The inner workings of our bodies, particularly what’s happening inside our cells, can be kind of a black box—with countless tiny molecules constantly working and churning to keep us alive. A new technology that blends bioluminescence with cellular machinery may shine some light on the details of their comings and goings and interactions that can be hazy.

Scientists had the bright idea to take that same enzyme that makes fireflies glow and tie it to RNA, the molecule that reads the genetic information in DNA. This developing technology has been used on mice, with the hope that these light-up molecules can help illuminate how viruses replicate or even how memories form in the brain.

Flora Litchtman talks with Dr. Andrej Lupták, professor of pharmaceutical sciences at the University of California Irvine and Dr. Jennifer Prescher, professor of chemistry at the University of California Irvine, about their research on the topic.


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Segment Guests

Andrej Lupták

Dr. Andrej Lupták is a professor of Pharmaceutical Sciences at the University of California Irvine in Irvine, California.

Jen Prescher

Dr. Jen Prescher is a professor of Chemistry at the University of California Irvine in Irvine, California.

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